THE EFFECT OF CHRONIC ETHANOL INTAKE ON BRAIN NGF LEVEL AND ON NGF-TARGET TISSUES OF ADULT MICE

被引：32

作者：

ALOE, L

BRACCILAUDIERO, L

TIRASSA, P

机构：

[1] Institute of Neurobiology, CNR, 00137 Rome

来源：

DRUG AND ALCOHOL DEPENDENCE | 1993年 / 31卷 / 02期

关键词：

ETHANOL; NERVE GROWTH FACTOR; HIPPOCAMPUS; HYPOTHALAMUS; BASAL FOREBRAIN NEURONS; CHOLINE-ACETYLTRANSFERASE;

D O I：

10.1016/0376-8716(93)90068-2

中图分类号：

R194 [卫生标准、卫生检查、医药管理];

学科分类号：

摘要：

The effect of ethanol consumption on the forebrain and hypothalamus of adult mice was investigated. A consistent decrease of biological activity and of nerve growth factor (NGF) immunoreactivity was observed in the hippocampus and hypothalamus of alcohol-treated mice. Biochemical studies also indicate that chronic ethanol intake causes a reduction in the level of choline-acetyltransferase in the septum, hippocampus and striatum, but not in the cortex and other brain regions. This study provides evidence that long-term ethanol intake causes impairment of brain NGF level and of the cholinergic enzyme, regulated by NGF, suggesting that NGF synthesis and/or biological activity is affected in alcohol-related brain neuropathology.

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页码：159 / 167

页数：9

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