DETERMINATION OF A COMMON CLONAL ORIGIN OF GASTRIC AND PULMONARY MUCOSA-ASSOCIATED LYMPHOID-TISSUE LYMPHOMAS PRESENTING 5 YEARS APART

被引：22

作者：

KAWAMATA, N

MIKI, T

FUKUDA, T

SUZUKI, K

SUMI, Y

OHDAMA, S

HIROSAWA, S

MATSUBARA, O

KAMIYAMA, R

AOKI, N

机构：

[1] First Department of Internal Medicine, Tokyo

[2] Second Division of Pathology, Tokyo

[3] School of Allied Health Sciences, Tokyo Medical and Dental University, Tokyo

来源：

INTERNAL MEDICINE | 1995年 / 34卷 / 03期

关键词：

REACTIVE LYMPHOID HYPERPLASIA; POLYMERASE CHAIN REACTION; COMPLEMENTARITY-DETERMINING REGION 3;

D O I：

10.2169/internalmedicine.34.220

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Mucosa-associated lymphoid tissue (MALT) lymphoma is often mis-diagnosed as a benign tumor. Dissemination to other sites occurs in MALT lymphoma. We report a 60-year-old man with gastric and pulmonary tumors of MALT lymphoma which occurred 5 years apart. Initially, the gastric tumor had been diagnosed as reactive lymphoreticular hyperplasia. To determine whether the two tumors arose from the same malignant clone, we amplified and sequenced the complementarity-determining region 3 of the immunoglobulin heavy chain gene using the polymerase chain reaction (PCR). The sequences were identical except for 11-nucleotide difference, suggesting identical clonality.

引用

页码：220 / 223

页数：4

共 15 条

[1]

Isaacson P.G., Wright D.H., Malignant lymphoma of mucosa-associated lymphoid tissue, Cancer, 52, (1983)

[2]

Isaacson P.G., Lymphomas of mucosa-associated lymphoid tissue (MALT), Histopathology, 16, (1990)

[3]

Saiki R.K., Scharf S., Faloona F., Et al., Enzymatic amplification of beta-globin genomic sequences and restriction site analysis for diagnosis of sickle cell anemia, Science, 230, (1985)

[4]

Yamada M., Hudson S., Tournay O., Et al., Detection of minimal disease in hematopoietic malignancies of the B-cell lineage by using third-complementarity-determining region (CDR-III)-specific probes, Proc Natl Acad Sci, 86, (1989)

[5]

Wright D.K., Manos M.M., Sample preparation from paraffin-embedded tissues, PCR Protocols-A Guide to Methods and Applications, (1990)

[6]

Maniatis T., Fritsch E.F., Sambrook J., Molecular Cloning, a Laboratory Manual, (1989)

[7]

Brisco M.J., Tan L.W., Orsborn A.M., Morley A.A., Development of a highly sensitive assay, based on the polymerase chain reaction, for rare B-lymphocyte clones in a polyclonal population, Br J Haematol, 75, (1990)

[8]

Trainor K.J., Brisco M.J., Story C.J., Morley A.A., Monoclonality in B-lymphoproliferative disorders detected at the DNA level, Blood, 75, (1990)

[9]

Ono H., Kondo H., Saito D., Et al., Rapid diagnosis of gastric malignant lymphoma from biopsy specimens: detection of immunoglobulin heavy chain rearrangement by polymerase chain reaction, Jpn J Cancer Res, 84, (1993)

[10]

Ichihara Y., Matsuoka H., Kurosawa Y., Organization of human immunoglobulin heavy chain diversity gene loci, EMBO J, 7, (1988)

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