A MECHANISM-BASED CLEAVAGE OF LACTAM-CARBAMATES

被引：22

作者：

WEI, ZY ^{[1
]}

KNAUS, EE ^{[1
]}

机构：

[1] UNIV ALBERTA,FAC PHARM,EDMONTON T6G 2N8,AB,CANADA

来源：

TETRAHEDRON LETTERS | 1994年 / 35卷 / 06期

基金：

英国医学研究理事会;

关键词：

D O I：

10.1016/S0040-4039(00)75979-X

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Magnesium methoxide is a simple, effective and highly selective reagent for the deprotection of N-alkoxycarbonyl lactams. The cleavage occurs via six-membered ring transition states involving coordination of magnesium ion with the oxygens of the carbamate and lactam carbonyl groups.

引用

页码：847 / 848

页数：2

共 7 条

[1] ASYMMETRIC-SYNTHESIS OF GAMMA,GAMMA-DIALKYL-GAMMA-AMINOBUTYRIC ACID ANALOGS AND 2,2-DISUBSTITUTED PYRROLIDINES - CONTROL OF STEREOCHEMISTRY IN AMINAL RING-OPENING BY VARYING THE EXTENT OF ALLYLIC 1,3-STRAIN [J].