SPREAD OF EPILEPTIFORM POTENTIALS IN THE NEOCORTICAL SLICE - RECORDINGS WITH VOLTAGE-SENSITIVE DYES

被引：13

作者：

ALBOWITZ, B

KUHNT, U

机构：

[1] Department of Neurobiology, Max-Planck-Institute for Biophysical Chemistry, 37018 Göttingen

来源：

BRAIN RESEARCH | 1993年 / 631卷 / 02期

关键词：

SENSORY NEOCORTEX; GUINEA PIG; EPILEPSY; SPREAD; OPTICAL RECORDING METHOD; VOLTAGE-SENSITIVE DYE;

D O I：

10.1016/0006-8993(93)91553-5

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The spread of epileptiform potentials in guinea pig neocortical slices was investigated by use of voltage sensitive dyes and a fast optical recording technique. Epileptiform activity was induced in a perfusion medium containing 10-20 mu M bicuculline-methiodide and by single pulse stimulation of layer I or the white matter. The location of minimal and maximal amplitudes, the shape of the potentials at specific sites and the velocity of spread were independent from the specific stimulation site. The expression of epileptiform activity appeared to depend on specific, possibly geometrical, properties of the tissue.

引用

页码：329 / 333

页数：5

共 20 条

[1] THE CONTRIBUTION OF INTRACORTICAL CONNECTIONS TO HORIZONTAL SPREAD OF ACTIVITY IN THE NEOCORTEX AS REVEALED BY VOLTAGE-SENSITIVE DYES AND A FAST OPTICAL-RECORDING METHOD [J].