TRACE DETERMINATION OF ACETAMINOPHEN IN SERUM

被引：27

作者：

MINER, DJ ^{[1
]}

KISSINGER, PT ^{[1
]}

机构：

[1] PURDUE UNIV, DEPT CHEM, W LAFAYETTE, IN 47907 USA

来源：

JOURNAL OF PHARMACEUTICAL SCIENCES | 1979年 / 68卷 / 01期

基金：

美国国家科学基金会;

关键词：

Acetaminophen—liquid chromatographic analysis in serum; Analgesics—acetaminophen; liquid chromatographic analysis in serum; Liquid chromatography—analysis; acetaminophen in serum;

D O I：

10.1002/jps.2600680130

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A simple and accurate method for measuring acetaminophen in serum was developed using liquid chromatography with electrochemical detection. Acetaminophen can be quantitated in 100 .mu.l of serum over the range of 20 ng/ml-20 .mu.g/ml. The method is linear (r [correlation coefficient] = 0.9997) and reproducible (RSD [relative standard deviation] = 3.0% at 2 .mu.g/ml, RSD = 5.1% at 200 ng/ml, n = 6). An internal standard (N-propionyl-p-aminophenol) is used and a single extraction is performed.

引用

页码：96 / 97

页数：2

共 10 条

[1] GLC MICROANALYSES OF PHENACETIN AND ACETAMINOPHEN PLASMA-LEVELS [J].