ABSENCE OF BOTH AUDITORY EVOKED-POTENTIALS AND AUDITORY PERCEPTS DEPENDENT ON TIMING CUES

被引：126

作者：

STARR, A ^{[1
]}

MCPHERSON, D ^{[1
]}

PATTERSON, J ^{[1
]}

DON, M ^{[1
]}

LUXFORD, W ^{[1
]}

SHANNON, R ^{[1
]}

SININGER, Y ^{[1
]}

TONAKAWA, L ^{[1
]}

WARING, M ^{[1
]}

机构：

[1] HOUSE EAR RES INST, LOS ANGELES, CA USA

来源：

BRAIN | 1991年 / 114卷

关键词：

D O I：

10.1093/brain/114.3.1157

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

An 11-yr-old girl had an absence of sensory components of auditory evoked potentials (brainstem, middle and long-latency) to click and tone burst stimuli that she could clearly hear. Psychoacoustic tests revealed a marked impairment of those auditory perceptions dependent on temporal cues, that is, lateralization of binaural clicks, change of binaural masked threshold with changes in signal phase, binaural beats, detection of paired monaural clicks, monaural detection of a silent gap in a sound, and monaural threshold elevation for short duration tones. In contrast, auditory functions reflecting intensity or frequency discriminations (difference limens) were only minimally impaired. Pure tone audiometry showed a moderate (50 dB) bilateral hearing loss with a disproportionate severe loss of word intelligibility. Those auditory evoked potentials that were preserved included (1) cochlear microphonics reflecting hair cell activity; (2) cortical sustained potentials reflecting processing of slowly changing signals; and (3) long-latency cognitive components (P300, processing negativity) reflecting endogenous auditory cognitive processes. Both the evoked potential and perceptual deficits are attributed to changes in temporal encoding of acoustic signals perhaps occurring at the synapse between hair cell and eight nerve dendrites. The results from this patient are discussed in relation to previously published cases with absent auditory evoked potentials and preserved hearing.

引用

页码：1157 / 1180

页数：24

共 63 条

[1] DISCRIMINATION OF TEMPORAL GAPS [J].