HIGH PREVALENCE OF HEPATITIS-B AND HEPATITIS-C VIRAL MARKERS IN JAPANESE PATIENTS WITH HEPATOCELLULAR-CARCINOMA

被引：8

作者：

TANAKA, N ^{[1
]}

CHIBA, T ^{[1
]}

MATSUZAKI, Y ^{[1
]}

OSUGA, T ^{[1
]}

AIKAWA, T ^{[1
]}

MITAMURA, K ^{[1
]}

机构：

[1] UNIV TSUKUBA,INST CLIN MED,DEPT MED,1-1-1 TENNODAI,TSUKUBA,IBARAKI 305,JAPAN

来源：

GASTROENTEROLOGIA JAPONICA | 1993年 / 28卷 / 04期

关键词：

HEPATITIS-B VIRAL MARKERS; HEPATITIS-C VIRAL MARKERS; HEPATOCELLULAR CARCINOMA; LIVER CIRRHOSIS;

D O I：

10.1007/BF02776954

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

In order to assess the etiologic role of hepatitis C virus (HCV) as well as hepatitis B virus (HBV) in the etiology of HCC, we compared the prevalence of HCV-related antibodies (anti-C100-3, anti-CP9, anti-CP10) and HBV-related markers (HBsAg, anti-HBs, anti-HBc) in sera of patients with liver cirrhosis (LC) with (n=62) and without (n=54) hepatocellular carcinoma (HCC). In HBsAg-negative cases, at least one HCV-related marker (including HCV RNA) was detected in 92.3% (48/52) of HCC cases and in all of the 44 LC cases without HCC, with no significant difference between these two groups. In HBsAg-positive cases, the prevalence of either one of these HCV-related markers was 40.0% (4/10) both in patients with and without HCC, and there was no significant difference between these two groups. Moreover, in HBsAg-negative cases and 11 cases of positive HCV-related markers, the prevalence of anti-HBs and/or anti-HBc was significantly higher in LC patients with HCC (85.4%) than those without HCC (43.2%, P<0.001). These results show a high prevalence of hepatitis B and C viral markers in Japanese patients with HCC and further indicate that previous HBV infection is a risk factor in the occurrence of HCC in HBsAg-negative LC and LC with positive HCV-related markers.

引用

页码：547 / 553

页数：7

共 35 条

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