CHIRAL ACETYLENIC SULFOXIDES IN ORGANIC-SYNTHESIS - SECONDARY AMINE CYCLIZATION AND TOTAL SYNTHESIS OF (S)-(-)-CARNEGINE

被引：26

作者：

CHAN, WH

LEE, AWM

JIANG, LS

机构：

[1] Department of Chemistry, Hong Kong Baptist College 224, Kowloon Tong, Kowloon, Waterloo Road

来源：

TETRAHEDRON LETTERS | 1995年 / 36卷 / 05期

关键词：

D O I：

10.1016/0040-4039(94)02323-4

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Michael addition of secondary amines 1b-1g onto chiral acetylenic sulfoxides 2 followed by acid induced cyclization afforded structures of tetrahydroisoquinoline skeleton in high to moderate diastereoselectivity. Optical pure (S)-(-)-carnegine has been synthesized.

引用

页码：715 / 718

页数：4

共 5 条

[1] CHIRAL ACETYLENIC SULFOXIDE IN ALKALOID SYNTHESIS - TOTAL SYNTHESIS OF (R)-(+)-CARNEGINE [J].