CLONING AND SEQUENCE OF THE CDNA CODING FOR RAT TYPE-II FC-GAMMA RECEPTOR OF MAST-CELLS

被引：13

作者：

BOCEK, P ^{[1
]}

PECHT, I ^{[1
]}

机构：

[1] WEIZMANN INST SCI, DEPT CHEM IMMUNOL, IL-76100 REHOVOT, ISRAEL

来源：

FEBS LETTERS | 1993年 / 331卷 / 1-2期

关键词：

FC-GAMMA RECEPTOR; RBL-2H3; MAST CELL;

D O I：

10.1016/0014-5793(93)80302-B

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A clone encoding the rat type II Fcgamma receptor was isolated from a cDNA library of the rat mucosal mast cell line RBL-2H3 and its sequence determined. The predicted amino acid sequence is highly homologous with the mouse type II as well as rat type III Fcgamma receptors. The site of alternative splicing which generates the mouse FcgammaRb2 isoform is completely conserved. Hence we consider the new sequence to encode a rat FcgammaRII b2 isoform. In further analogy to the mouse receptor, no consensus motif known to be involved in accessory chain association was observed in the transmembranal domain. The importance of the identification of this receptor for investigation of the immunological stimulation of mast cells is discussed.

引用

页码：86 / 90

页数：5

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