BIOSYNTHESIS OF WITHANOLIDES IN ACNISTUS-BREVIFLORUS - INCORPORATION OF LABELED 24-METHYLENECHOLESTEROL

被引：4

作者：

MONTEAGUDO, ES

BURTON, G

GROS, EG

机构：

[1] Departamento de Química Orgánica, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, 1428 Buenos Aires, Pab. 2, Ciudad Universitaria

来源：

PHYTOCHEMISTRY | 1994年 / 35卷 / 04期

关键词：

ACNISTUS-BREVIFLORUS; SOLANACEAE; WITHANOLIDES; WITHAFERIN-A; JABOROSALACTONE-A; JABOROSALACTONE-D; 24-METHYLENECHOLESTEROL; BIOSYNTHESIS;

D O I：

10.1016/S0031-9422(00)90640-X

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Feeding experiments with [24-C-14] 24-methylenecholesterol and mixtures of this sterol and [7-H-3] 24-methylenecholesterol were performed to study the biosynthesis of withanolides in the plant Acnistus breviflorus. The results indicate that the side chain of the sterol precursor should be broken between C-24 and C-25 to give an intermediate which follows the biogenetic pathway into withaferin A, jaborosalactone A and jaborosalactone D.

引用

页码：927 / 929

页数：3

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