PHARMACOLOGICAL AND INVITRO COMPARISON OF 3 ORAL CEPHALOSPORINS

被引：14

作者：

WISE, R ^{[1
]}

ANDREWS, JM ^{[1
]}

DEAN, S ^{[1
]}

WELLING, PG ^{[1
]}

KENDALL, MJ ^{[1
]}

机构：

[1] QUEEN ELIZABETH HOSP,DEPT THERAPEUT & CLIN PHARMACOL,BIRMINGHAM B15 2TH,W MIDLANDS,ENGLAND

来源：

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY | 1979年 / 5卷 / 05期

关键词：

D O I：

10.1093/jac/5.5.601

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

The pharmacology of cephradine, cephalexin and a new oral cephalosporin, cefaclor, has been compared in six volunteers. Cefaclor was absorbed rapidly and was cleared from the serum more rapidly than the other two agents. This was probably partially due to its instability in serum at body temperature, which was investigated.Against a wide range of common pathogens cefador was the more active oral cephalosporin. In particular the activity against Neisserla gonorrhoeae and Haemophilus influenzae was of interest. © 1979, by The British Society for Antimicrobial Chemotherapy.

引用

页码：601 / 607

页数：7

共 11 条

[1]

Bill N.J., Washington J.A., Comparison of in vitro activity of cephalexin, cephradine and cefaclor, Antimicrobial Agents and Chemotherapy, 11, pp. 470-474, (1977)

[2]

Eykyn S., Jenkins C., King A., Phillips I., Antibacterial activity of cefuroxime, a new cephalosporin antibiotic, compared with that of cephaloridine, cephalothin and cefamandole, Antimicrobial Agents and Chemotherapy, 9, pp. 689-695, (1976)

[3]

Fowle A.S.E., Aspects of the pharmacokinetic behaviour of trimethoprim and sulphamethoxa- zole, Trimethoprim!Sulphamethoxazole in Bacterial Infections, pp. 63-72, (1973)

[4]

Glynne A., Goulboum R.A., Ryden R., A human pharmacology study of cefaclor, Journal of Antimicrobial Chemotherapy, 4, pp. 343-348, (1978)

[5]

Kayser F., H. In vitro activity of cephalosporin antibiotics against Gram-positive bacteria. Postgraduate Medical Journal (Feb, Postgraduate Medical Journal, 47, pp. 14-20, (1971)

[6]

Nightingale C.H., Greene D.S., Quintiliani R., Pharmacokinetics and clinical use of cephalosporin antibiotics, Journal of Pharmaceutical Science, 64, pp. 1899-1926, (1975)

[7]

Rolinson G.N., Macdonald A.C., Wilson D.A., Bactericidal Action of 8-Lactam Antibiotics On, 3, pp. 541-553, (1977)

[8]

Selwyn S., Rational choice of penicillins and cephalosporins based on parallel in vitro and in vivo tests, Lancet Ii, (1976)

[9]

Smith A.L., Antibiotics and invasive, H. Influenzae. New England Journal of Medicine, 294, pp. 1329-1331, (1976)

[10]

Wise R., Table of expected concentrations of antibiotics, Antibacterial Chemotherapy, pp. 151-156, (1978)

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