RELATIONSHIP BETWEEN STEADY-STATE PLASMA NIZATIDINE CONCENTRATIONS AND INHIBITION OF BASAL AND STIMULATED GASTRIC-ACID SECRETION

被引：4

作者：

SCHNECK, DW

CALLAGHAN, JT

BERGSTROM, RF

OBERMEYER, BD

OFFEN, WW

机构：

[1] ELI LILLY INT CORP,LILLY LABS CLIN RES,INDIANAPOLIS,IN 46285

[2] INDIANA UNIV,SCH MED,DEPT MED & PHARMACOL,INDIANAPOLIS,IN 46202

来源：

CLINICAL PHARMACOLOGY & THERAPEUTICS | 1990年 / 47卷 / 04期

关键词：

D O I：

10.1038/clpt.1990.63

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Steady-state plasma nizatidine concentrations were related in a linear fashion to nizatidine infusion rate. Infusion rates of 2.5, 10, and 20 mg/hr resulted in mean plasma nizatidine concentrations of 69, 247, and 575 ng/ml. Basal acid secretion was inhibited by 50% and 90% at mean plasma nizatidine concentrations of 60 and 430 ng/ml. Protein-stimulated acid secretion was inhibited by 50% and 90% at mean plasma nizatidine concentrations of 75 and 490 ng/ml. The mean pH of basal gastric secretions was 1.6 during placebo infusion and 4.6 when the mean plasma nizatidine concentration was 575 ng/ml. © 1990.

引用

页码：499 / 503

页数：5

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