DISTRIBUTION OF HLA-DQA1, HLA-DQB1 AND DRB1 ALLELES IN BLACK IDDM PATIENTS AND CONTROLS FROM ZIMBABWE

被引：37

作者：

GARCIAPACHECO, JM

HERBUT, B

CUTBUSH, S

HITMAN, GA

ZHONGLIN, W

MAGZOUB, M

BOTTAZZO, GF

KIERE, C

WEST, G

MVERE, D

BIRO, PA

SACHS, JA

机构：

[1] UNIV LONDON LONDON HOSP,COLL MED,DEPT IMMUNOL,TURNER ST,LONDON E1 2AD,ENGLAND

[2] UNIV LONDON LONDON HOSP,COLL MED,MED UNIT,LONDON E1 2AD,ENGLAND

[3] MED SCH HARARE,DEPT MED,HARARE,ZIMBABWE

[4] BLOOD TRANSFUS SERV,HARARE,ZIMBABWE

来源：

TISSUE ANTIGENS | 1992年 / 40卷 / 03期

关键词：

ZIMBABWEAN; OLIGOTYPING; HLA-DQ-DR POLYMORPHISM; IDDM;

D O I：

10.1111/j.1399-0039.1992.tb02107.x

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

We have used the XI Histocompatibility Workshop sequence-specific oligonucleotide probes to determine the DRB1, DQA1 and DQBI genotypes by dot-blot hybridization of polymerase chain reaction (pcr)-amplified material from a homogenous black population in Zimbabwe. The DR4 subtype DRB1*0405, the DR3 subtype DRB1*0301, DQB1*0201 and DQB1*0302 and DQA1*0301 and DQA1*0501 were significantly increased in the IDDM group compared to the controls, whereas DRB1*11, DQBI*0602 and DQA1*0102 were significantly decreased. Taken together, the data show that susceptibility and resistance to IDDM are associated both with particular haplotypes and DQA1-DQB1 heterodimers without one or other being overriding,

引用

页码：145 / 149

页数：5

共 17 条

[1]

ASPARICIO JMR, 1988, IMMUNOGENETICS, V28, P240

[2] HIGH-FREQUENCY OF ASPARTIC-ACID AT POSITION-57 OF HLA-DQ BETA-CHAIN IN JAPANESE IDDM PATIENTS AND NONDIABETIC SUBJECTS [J].