CHANGES IN HEPATIC COLLAGEN PRODUCED BY CHRONIC INTOXICATION OF RATS WITH ETHANOL

被引：2

作者：

BANKOWSKI, E

PAWLICKA, E

机构：

[1] Department of Biochemistry, Medical Academy of Bialystok, 15-230 Bialystok 8

来源：

ALCOHOL | 1993年 / 10卷 / 02期

关键词：

COLLAGEN; ETHANOL; LIVER; RAT;

D O I：

10.1016/0741-8329(93)90094-5

中图分类号：

R194 [卫生标准、卫生检查、医药管理];

学科分类号：

摘要：

It was decided to study the effect of chronic intoxication of rats with ethanol on collagen content in the liver, its solubility, and molecular polymorphism. It was found that treatment of rats with 10% ethanol instead of drinking water for 6 months resulted in a 50% increase of collagen content in livers of the investigated animals. Significant changes in quantitative relationships between types I, III, and V collagens were observed. Proportional amounts of type III and V collagens were higher and type I collagen was lower in comparison to those in control rat liver.

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页码：145 / 148

页数：4

相关论文

共 31 条

[1] IS ALCOHOL HEPATOTOXIC IN THE BABOON [J].

AINLEY, CC ;

SENAPATI, A ;

BROWN, IMH ;

ILES, CA ;

SLAVIN, BM ;

MITCHELL, WD ;

DAVIES, DR ;

KEELING, PWN ;

THOMPSON, RPH .

JOURNAL OF HEPATOLOGY, 1988, 7 (01) :85-92

[2] AN INCREASE OF COLLAGEN BIOSYNTHESIS IN LIVERS OF RATS SUBMITTED TO CHRONIC INTOXICATION WITH ETHANOL [J].

BANKOWSKI, E ;

PAWLICKA, E .

MOLECULAR AND CELLULAR BIOCHEMISTRY, 1989, 85 (01) :43-48

[3] PROLYL HYDROXYLASE-ACTIVITY AS AN INDEX OF LIVER-DAMAGE INDUCED BY ETHANOL [J].

BANKOWSKI, E ;

PAWLICKA, E ;

JODCZYK, KJ .

CELL BIOCHEMISTRY AND FUNCTION, 1987, 5 (03) :211-215

[4] TEMPORAL EFFECTS OF ETHANOL ON GROWTH, THYMIDINE UPTAKE, PROTEIN AND COLLAGEN PRODUCTION IN HUMAN FETAL LUNG FIBROBLASTS [J].

BARNES, Y ;

HOUSER, S ;

BARILE, FA .

TOXICOLOGY IN VITRO, 1990, 4 (01) :1-7

[5] CHRONIC ADMINISTRATION OF ETHANOL WITH HIGH VITAMIN-A SUPPLEMENTATION IN A LIQUID DIET TO RATS DOES NOT CAUSE LIVER FIBROSIS .1. MORPHOLOGICAL OBSERVATIONS [J].

BOSMA, A ;

SEIFERT, WF ;

WILSON, JHP ;

ROHOLL, PJM ;

BROUWER, A ;

KNOOK, DL .

JOURNAL OF HEPATOLOGY, 1991, 13 (02) :240-248

[6]

BRENNER DA, 1987, J BIOL CHEM, V262, P17690

[7] HEPATIC COLLAGEN METABOLISM - EFFECT OF ALCOHOL CONSUMPTION IN RATS AND BABOONS [J].

FEINMAN, L ;

LIEBER, CS .

SCIENCE, 1972, 176 (4036) :795-&

[8] ACETALDEHYDE STIMULATES COLLAGEN AND NONCOLLAGEN PROTEIN-PRODUCTION BY HUMAN-FIBROBLASTS [J].

HOLT, K ;

BENNETT, M ;

CHOJKIER, M .

HEPATOLOGY, 1984, 4 (05) :843-848

[9]

KATO S, 1985, RES COMMUN CHEM PATH, V47, P163

[10] LUNG COLLAGEN - MORE THAN SCAFFOLDING [J].

LAURENT, GJ .

THORAX, 1986, 41 (06) :418-428

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