1-THIO-BETA-D-GALACTOSE AS A CHIRAL DERIVATIZATION AGENT FOR THE RESOLUTION OF D,L-AMINO ACID ENANTIOMERS

被引：13

作者：

JEGOROV, A

TRISKA, J

TRNKA, T

机构：

[1] ACAD SCI CZECH REPUBL,CR-37005 CESKE BUDEJOVICE,CZECH REPUBLIC

[2] CHARLES UNIV,DEPT ORGAN CHEM,CR-12840 PRAGUE,CZECH REPUBLIC

来源：

JOURNAL OF CHROMATOGRAPHY A | 1994年 / 673卷 / 02期

关键词：

D O I：

10.1016/0021-9673(94)85045-3

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

o-Phthaldialdehyde in combination with 1-thio-beta-D-galactose is a powerful chiral reagent for the precolumn derivatization of primary amino acids. The diastereomers formed can be efficiently resolved on conventional reversed-phase columns. Comparison of 1-thio-beta-D-galactose with 1-thio-beta-D-glucose revealed that even the change of the configuration of the remote OH group on the sugar moiety influences the resolution of D,L-amino acid derivatives.

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页码：286 / 290

页数：5

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