TRISOMY-12 IN B-CELL CHRONIC LYMPHOCYTIC-LEUKEMIA - AN EVALUATION OF 33 PATIENTS BY DIRECT FLUORESCENCE IN-SITU HYBRIDIZATION (FISH)

被引：16

作者：

BIENZ, N

CARDY, DLN

LEYLAND, MJ

HULTEN, MA

机构：

[1] E BIRMINGHAM DIST GEN HOSP,DEPT HAEMATOL,BIRMINGHAM B9 5ST,W MIDLANDS,ENGLAND

[2] E BIRMINGHAM DIST GEN HOSP,DEPT CYTOGENET,BIRMINGHAM B9 5ST,W MIDLANDS,ENGLAND

来源：

BRITISH JOURNAL OF HAEMATOLOGY | 1993年 / 85卷 / 04期

关键词：

D O I：

10.1111/j.1365-2141.1993.tb03233.x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

An adaptation of the standard fluorescence in situ hybridization (FISH) technique allowing rapid analysis (4 h) has been used to study the prevalence of trisomy 12 in 33 patients with B-CLL, of whom 54% have been shown to have this abnormality. The presence of trisomy 12 has been compared with clinical parameters, and there may be a relationship between the prevalence of trisomy 12 in B-CLL and duration of disease.

引用

页码：819 / 822

页数：4

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