PROTEIN-TYROSINE-PHOSPHATASE 1D MODULATES ITS OWN STATE OF TYROSINE PHOSPHORYLATION

被引：39

作者：

GERLACH, MS ^{[1
]}

KHARITONENKOV, A ^{[1
]}

VOGEL, W ^{[1
]}

ALI, S ^{[1
]}

ULLRICH, A ^{[1
]}

机构：

[1] MAX PLANCK INST BIOCHEM,DEPT MOLEC BIOL,D-82152 MARTINSRIED,GERMANY

来源：

JOURNAL OF BIOLOGICAL CHEMISTRY | 1995年 / 270卷 / 42期

关键词：

D O I：

10.1074/jbc.270.42.24635

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The insulin receptor-mediated signal transduction pathway involves insulin receptor substrate 1 and a variety of proteins containing Src homology-g (SH2) domains, such as phosphatidylinositol S-kinase, Grb2, and protein-tyrosine phosphatase 1D (PTP1D). Upon insulin stimulation of baby hamster kidney cells overexpressing the IR, the catalytically inactive mutant of PTP1D, C463A, becomes tyrosine-phosphorylated and coprecipitates with Grb2. Tyrosine phosphorylation of this mutant is significantly reduced when wild type PTP1D is coexpressed. Substitution of tyrosine residues 546 and 584 with phenylalanine abrogates tyrosine phosphorylation of the catalytically inactive mutant and abolishes its interaction with Grb2.

引用

页码：24635 / 24637

页数：3

共 37 条

[1] MOLECULAR-CLONING OF A NOVEL PROTEIN-TYROSINE PHOSPHATASE SH-PTP3 WITH SEQUENCE SIMILARITY TO THE SRC-HOMOLOGY REGION-2 [J].

ADACHI, M ;

SEKIYA, M ;

MIYACHI, T ;

MATSUNO, K ;

HINODA, Y ;

IMAI, K ;

YACHI, A .

FEBS LETTERS, 1992, 314 (03) :335-339

[2] A WIDELY EXPRESSED HUMAN PROTEIN-TYROSINE PHOSPHATASE CONTAINING SRC HOMOLOGY-2 DOMAINS [J].

AHMAD, S ;

BANVILLE, D ;

ZHAO, ZZ ;

FISCHER, EH ;

SHEN, SH .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1993, 90 (06) :2197-2201

[3] PHOSPHATIDYLINOSITOL 3'-KINASE IS ACTIVATED BY ASSOCIATION WITH IRS-1 DURING INSULIN STIMULATION [J].

BACKER, JM ;

MYERS, MG ;

SHOELSON, SE ;

CHIN, DJ ;

SUN, XJ ;

MIRALPEIX, M ;

HU, P ;

MARGOLIS, B ;

SKOLNIK, EY ;

SCHLESSINGER, J ;

WHITE, MF .

EMBO JOURNAL, 1992, 11 (09) :3469-3479

[4] BINDING OF THE RAS ACTIVATOR SON OF SEVENLESS TO INSULIN-RECEPTOR SUBSTRATE-1 SIGNALING COMPLEXES [J].

BALTENSPERGER, K ;

KOZMA, LM ;

CHERNIACK, AD ;

KLARLUND, JK ;

CHAWLA, A ;

BANERJEE, U ;

CZECH, MP .

SCIENCE, 1993, 260 (5116) :1950-1952

[5] CLONING, EXPRESSION AND MUTATIONAL ANALYSIS OF SH-PTP2, HUMAN PROTEIN-TYROSINE-PHOSPHATASE [J].

BASTIEN, L ;

RAMACHANDRAN, C ;

LIU, S ;

ADAM, M .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1993, 196 (01) :124-133

[6] PROTEIN-TYROSINE-PHOSPHATASE SHPTP2 COUPLES PLATELET-DERIVED GROWTH-FACTOR RECEPTOR-BETA TO RAS [J].

BENNETT, AM ;

TANG, TL ;

SUGIMOTO, S ;

WALSH, CT ;

NEEL, BG .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1994, 91 (15) :7335-7339

[7] HIGH-EFFICIENCY TRANSFORMATION OF MAMMALIAN-CELLS BY PLASMID DNA [J].

CHEN, C ;

OKAYAMA, H .

MOLECULAR AND CELLULAR BIOLOGY, 1987, 7 (08) :2745-2752

[8]

FENG GS, 1994, ONCOGENE, V9, P1545

[9] SH2-CONTAINING PHOSPHOTYROSINE PHOSPHATASE AS A TARGET OF PROTEIN-TYROSINE KINASES [J].

FENG, GS ;

HUI, CC ;

PAWSON, T .

SCIENCE, 1993, 259 (5101) :1607-1611

[10] IDENTIFICATION OF A HUMAN SRC HOMOLOGY 2-CONTAINING PROTEIN-TYROSINE-PHOSPHATASE - A PUTATIVE HOMOLOG OF DROSOPHILA CORKSCREW [J].

FREEMAN, RM ;

PLUTZKY, J ;

NEEL, BG .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1992, 89 (23) :11239-11243

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