THE EFFECT OF SPACE AND PARABOLIC FLIGHT ON MACROPHAGE HEMATOPOIESIS AND FUNCTION

被引：51

作者：

ARMSTRONG, JW ^{[1
]}

GERREN, RA ^{[1
]}

CHAPES, SK ^{[1
]}

机构：

[1] KANSAS STATE UNIV AGR & APPL SCI,DIV BIOL,MANHATTAN,KS 66506

来源：

EXPERIMENTAL CELL RESEARCH | 1995年 / 216卷 / 01期

关键词：

D O I：

10.1006/excr.1995.1020

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

We used weak electric fields to monitor macrophage spreading in microgravity, Using this technique, we demonstrated that bone marrow-derived macrophages responded to microgravity within 8 s, We also showed that microgravity differentially altered two processes associated with bone marrow-derived macrophage development. Spaceflight enhanced cellular proliferation and inhibited differentiation. These data indicate that the space/microgravity environment significantly affects macrophages. (C) 1995 Academic Press, Inc.

引用

页码：160 / 168

页数：9

共 43 条

[1] CYTOKINES - COORDINATORS OF IMMUNE AND INFLAMMATORY RESPONSES [J].

ARAI, K ;

LEE, F ;

MIYAJIMA, A ;

MIYATAKE, S ;

ARAI, N ;

YOKOTA, T .

ANNUAL REVIEW OF BIOCHEMISTRY, 1990, 59 :783-836

[2] SKELETAL UNLOADING CAUSES ORGAN-SPECIFIC CHANGES IN IMMUNE CELL RESPONSES [J].

ARMSTRONG, JW ;

NELSON, KA ;

SIMSKE, SJ ;

LUTTGES, MW ;

IANDOLO, JJ ;

CHAPES, SK .

JOURNAL OF APPLIED PHYSIOLOGY, 1993, 75 (06) :2734-2739

[3] INTERLEUKIN-2 THERAPY REVERSES SOME IMMUNOSUPPRESSIVE EFFECTS OF SKELETAL UNLOADING [J].

ARMSTRONG, JW ;

BALCH, S ;

CHAPES, SK .

JOURNAL OF APPLIED PHYSIOLOGY, 1994, 77 (02) :584-589

[4]

ARMSTRONG JW, 1994, J EXP ZOOL, V269, P187

[5] ACTIVATION OF MICROCARRIER-ATTACHED LYMPHOCYTES IN MICROGRAVITY [J].

BECHLER, B ;

COGOLI, A ;

COGOLIGREUTER, M ;

MULLER, O ;

HUNZINGER, E ;

CRISWELL, SB .

BIOTECHNOLOGY AND BIOENGINEERING, 1992, 40 (08) :991-996

[6]

BOOCOCK CA, 1989, J CELL SCI, V93, P447

[7] CYTOKINE SECRETION BY IMMUNE CELLS IN SPACE [J].

CHAPES, SK ;

MORRISON, DR ;

GUIKEMA, JA ;

LEWIS, ML ;

SPOONER, BS .

JOURNAL OF LEUKOCYTE BIOLOGY, 1992, 52 (01) :104-110

[8]

CHAPES SK, 1988, J LEUKOCYTE BIOL, V42, P28

[9] MITOGENIC SIGNAL-TRANSDUCTION IN T-LYMPHOCYTES IN MICROGRAVITY [J].

COGOLI, A ;

BECHLER, B ;

COGOLIGREUTER, M ;

CRISWELL, SB ;

JOLLER, H ;

JOLLER, P ;

HUNZINGER, E ;

MULLER, O .

JOURNAL OF LEUKOCYTE BIOLOGY, 1993, 53 (05) :569-575

[10]

COGOLI A, 1980, AVIAT SPACE ENVIR MD, V51, P29

← 1 2 3 4 5 →