PROGNOSTIC SIGNIFICANCE OF RADIOLOGICAL AND SYMPTOMATIC BONE INVOLVEMENT IN CHILDHOOD ACUTE LYMPHOBLASTIC LEUKEMIA

被引：39

作者：

HANN, IM ^{[1
]}

GUPTA, S ^{[1
]}

PALMER, MK ^{[1
]}

MORRISJONES, PH ^{[1
]}

机构：

[1] ROYAL MANCHESTER CHILDRENS HOSP,DEPT PAEDIAT ONCOL,MANCHESTER M27 1HA,ENGLAND

来源：

MEDICAL AND PEDIATRIC ONCOLOGY | 1979年 / 6卷 / 01期

关键词：

acute lymphoblastic leukaemia; bone; children; prognosis;

D O I：

10.1002/mpo.2950060108

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Full skeletal survey was performed on 193 consecutive children presenting over a 6‐year period with acute lymphoblastic leukaemia (ALL). A record was made of the degree of bone pain in these patients and 60 others presenting immediately prior to the availability of skeletal surveys. Bone pain was present in 76 out of 253 patients (30%) and radiological bone changes characteristic of leukaemia in 125 out of 193 (65%). A significant correlation was found between the severity of bone pain and the number of bones involved on × ray (r = 0.25, P = <0.001), but not between initial white cell counts and bone score (r =‐0.14, P = 0.08). There was no significant correlation between the degree of bone pain and survival or length of first remission (P = 0.29 and 0.86). Similarly, the extent of radiological bone disease was of no prognostic significance with relation to survival (P = 0.41) or length of first remission (P = 0.21). Copyright © 1979 Wiley‐Liss, Inc., A Wiley Company

引用

页码：51 / 55

页数：5

共 12 条

[1] Masera G, Carnelli V, Ferrari M, Bellini F, Prognostic significance of radiological bone involvement in childhood ALL, Arch Dis Child, 52, pp. 530-533, (1977)
[2] Bellini F, Masera G, Carnelli V, DeLuca A, Ferrari M, Routine whole skeleton x‐ray investigation of 116 children with leukaemia, Ann Radiol, 19, pp. 83-86, (1976)
[3] Kundel DW, Brecher G, Bodey GP, Brittin GM, Reticulin fibrosis and bone infarction in acute leukaemia implications for prognosis, Blood, 23, pp. 526-544, (1964)
[4] Nies BA, Kundel DW, Thomas LB, Freireich EJ, Leucopenia, bone pain and bone necrosis in patients with acute leukaemia, Ann Intl Med, 62, pp. 698-705, (1965)
[5] Aur JA, Westbrook HW, Riggs W, Childhood acute lymphoblastic leukaemia–initial bone involvement and prognosis, Am J Dis Child, 124, pp. 653-654, (1972)
[6] Thomas LB, Forkner CE, Frei E, The skeletal lesions of acute leukaemia, Cancer, 14, pp. 608-621, (1961)
[7] (1964)
[8] Peto R, Pike MC, Armitage P, Breslow NE, Cox DR, Howard SV, Mantel N, McPherson K, Peto J, Smith PG, Design and analysis of randomised clinical trials requiring prolonged observation of each patient. II. Analysis and examples, Br J Cancer, 35, pp. 1-39, (1977)
[9] Wilson JKV, The bone lesions of childhood leukaemia. A survey of 140 cases, Radiology, 72, pp. 672-680, (1959)
[10] Silverman FN, The skeletal lesions in leukaemia, clinical and x‐ray observations in 103 infants and chldren, Am J Roentgenol Radium Therap Nucl Med, 59, pp. 819-845, (1948)

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