EFFECTIVE POSTEXPOSURE TREATMENT OF RABIES-INFECTED SHEEP WITH RABIES IMMUNE GLOBULIN AND VACCINE

被引：7

作者：

BLANCOU, J ^{[1
]}

BALTAZAR, RS ^{[1
]}

MOLLI, I ^{[1
]}

STOLTZ, JF ^{[1
]}

机构：

[1] CTR REG TRANSFUS SANGUINE & HEMATOL,F-54500 VANDOEUVRE NANCY,FRANCE

来源：

VACCINE | 1991年 / 9卷 / 06期

关键词：

RABIES; VIRUS; SHEEP; VACCINE; IMMUNOGLOBULIN; MODEL;

D O I：

10.1016/0264-410X(91)90131-O

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

An experiment to assess the efficiency of the treatment recommended for humans after exposure to rabies was conducted in 68 sheep experimentally infected with a fox rabies virus. The infected sheep were divided into three groups and were given either a cell-culture vaccine (on the day of infection, then at day 3, 7, 14), human rabies immunoglobulin (26 IU kg-1 on the day of infection) or a combination of the vaccine and immunoglobulin. The latter combination was the only treatment found to be effective in 100% of the animals, as 71% of the controls died. This model appears to be useful in assessing new regimens of postexposure treatment for humans as well as in the reconsideration of its feasibility, or validity, in animals.

引用

页码：432 / 437

页数：6

共 27 条

[1]

BAER GM, 1979, B WORLD HEALTH ORGAN, V57, P807

[2] SUCCESSFUL PROPHYLAXIS AGAINST RABIES IN MICE AND RHESUS-MONKEYS - INTERFERON SYSTEM AND VACCINE [J].

BAER, GM ;

SHADDOCK, JH ;

MOORE, SA ;

YAGER, PA ;

BARON, SS ;

LEVY, HB .

JOURNAL OF INFECTIOUS DISEASES, 1977, 136 (02) :286-291

[3] MODEL IN MICE FOR PATHOGENESIS AND TREATMENT OF RABIES [J].

BAER, GM ;

CLEARY, WF .

JOURNAL OF INFECTIOUS DISEASES, 1972, 125 (05) :520-&

[4]

BAER GM, 1988, REV INFECT DIS S4, V10, P739

[5]

BAER GM, 1975, NATURAL HIST RABIES, V1

[6]

BALTAZARD M, 1955, Bull World Health Organ, V13, P747

[7]

BIJLENGA G, 1977, REV I PASTEUR LYON, V10, P35

[8] A MODEL IN MICE FOR THE STUDY OF THE EARLY DEATH PHENOMENON AFTER VACCINATION AND CHALLENGE WITH RABIES VIRUS [J].

BLANCOU, J ;

ANDRAL, B ;

ANDRAL, L .

JOURNAL OF GENERAL VIROLOGY, 1980, 50 (OCT) :433-435

[9]

BLANCOU J, 1987, B LAB VET, V25, P9

[10]

DEAN DJ, 1963, B WORLD HEALTH ORGAN, V28, P477

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