CONCENTRATION OF OFLOXACIN AND CIPROFLOXACIN IN HUMAN SEMEN FOLLOWING A SINGLE ORAL DOSE

被引：9

作者：

BERGER, SA

YAVETZ, H

PAZ, G

GOREA, A

HOMONNAI, Z

机构：

[1] TEL AVIV MED CTR & SCH MED,INST MALE FERTIL,TEL AVIV,ISRAEL

[2] TEL AVIV MED CTR & SCH MED,DEPT MICROBIOL,TEL AVIV,ISRAEL

来源：

JOURNAL OF UROLOGY | 1990年 / 144卷 / 03期

关键词：

D O I：

10.1016/S0022-5347(17)39554-X

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

A single oral dose of ofloxacin (400 mg.) or ciprofloxacin (500 mg.) was administered to each of 40 men. The mean concentrations of ofloxacin in semen exceeded those of ciprofloxacin at 1 hour (p = 0.035) and 24 hours (p = 0.028), while the levels of the 2 drugs at 2 and 4 hours were comparable. Semen concentrations of ofloxacin but not ciprofloxacin exceeded the reported minimal inhibitory concentration of Enterobacteriaceae, Chlamydia trachomatis and genital Mycoplasma species 24 hours after dosage.

引用

页码：683 / 684

页数：2

共 7 条

[1] CIPROFLOXACIN, A QUINOLONE CARBOXYLIC-ACID COMPOUND ACTIVE AGAINST AEROBIC AND ANAEROBIC-BACTERIA [J].