TANDEM CONJUGATE ADDITION-ALDOL REACTION TO ALPHA,BETA-UNSATURATED ESTERS AND KETONES USING TITANIUM AMIDE

被引：23

作者：

HOSOMI, A

YANAGI, T

HOJO, M

机构：

[1] Department of Chemistry, University of Tsukuba, Tsukuba, Ibaraki

来源：

TETRAHEDRON LETTERS | 1991年 / 32卷 / 21期

关键词：

D O I：

10.1016/S0040-4039(00)79926-6

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Titanium dialkylamide, readily available, adds to alpha-beta-unsaturated esters and ketones in a conjugate addition mode to give ester and ketone enolates, respectively, which are successively quenched with electrophiles such as aldehydes and acetals. The aldol products can be readily converted to the corresponding deaminated or dehydrated derivatives selectively.

引用

页码：2371 / 2374

页数：4

共 16 条

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