CHARACTERIZATION OF POLYMORPHIC LOCI ON A TELOMERIC FRAGMENT OF DNA FROM THE LONG ARM OF HUMAN CHROMOSOME-7

被引：9

作者：

DIETZBAND, J

RIETHMAN, H

HILDEBRAND, CE

MOYZIS, R

机构：

[1] UNIV CALIF LOS ALAMOS SCI LAB,CTR HUMAN GENOME STUDIES,LOS ALAMOS,NM 87545

[2] WASHINGTON UNIV,SCH MED,DEPT GENET,ST LOUIS,MO 63110

来源：

GENOMICS | 1990年 / 8卷 / 01期

关键词：

D O I：

10.1016/0888-7543(90)90240-U

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

The 240-kb yeast artificial chromosome (YAC) HTY146 (D7S427) containing the telomere from the q arm of human chromosome 7 was subcloned into the cosmid vector sCOS-1. Cosmid subclones were screened for DNA polymorphisms by Southern blot analysis of restriction digests of DNA from random individuals. Four distinct polymorphisms were characterized. These markers provide a resource for defining the end of the genetic map for the long arm of human chromosome 7. © 1990.

引用

页码：168 / 170

页数：3

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