BOMBESIN STIMULATES THE RELEASE OF INSULIN AND GLUCAGON, BUT NOT PANCREATIC SOMATOSTATIN, FROM THE ISOLATED PERFUSED DOG PANCREAS

Synthetic bombesin, perfused in the isolated canine pancreas at a rate of 340-380 ng/min for 10 min, elicited a 4-fold rise in insulin to a peak at 2 min; a rapid decline followed discontinuation of bombesin. Glucagon rose by 50% to a peak at 6 min, but remained elevated after discontinuation of the bombesin. Somato-statin-like immunoreactivity was not significantly affected by perfusion with bombesin. © 1979 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted.