EFFECT OF INTRACEREBROVENTRICULAR INJECTION OF IGF-I ON CIRCULATING GROWTH-HORMONE CONCENTRATIONS IN THE SHEEP

被引：35

作者：

SPENCER, GSG ^{[1
]}

BASS, JJ ^{[1
]}

HODGKINSON, SC ^{[1
]}

EDGLEY, WHR ^{[1
]}

MOORE, LG ^{[1
]}

机构：

[1] WALLACEVILLE AGR CTR,WALLACEVILLE,NEW ZEALAND

来源：

DOMESTIC ANIMAL ENDOCRINOLOGY | 1991年 / 8卷 / 01期

关键词：

D O I：

10.1016/0739-7240(91)90049-P

中图分类号：

S8 [畜牧、动物医学、狩猎、蚕、蜂];

学科分类号：

0905 ;

摘要：

The effect of intracerebroventricular administration of IGF-1 on circulating growth hormone (GH) concentrations has been studied in sheep. Twenty sheep were fitted with jugular vein catheters and with indwelling cerebroventricular cannulae. IGF-I was injected into a lateral cerebral ventricle and changes in the circulating concentrations of GH were measured in jugular vein blood samples. Administration of saline had no effect on circulating GH concentrations over a 3-hr period, and administration of IGF-I (at 1, 3 and 10-mu-g/sheep) also had no significant effect on circulating GH concentrations. From these data we surmise that centrally administered IGF-I does not influence GH secretion and it seems probable that cerebrospinal fluid concentrations of IGF-I do not have a role in regulating GH release in sheep.

引用

页码：155 / 160

页数：6

共 14 条

[1] HUMAN GROWTH-HORMONE AND SOMATOMEDIN-C SUPPRESS THE SPONTANEOUS RELEASE OF GROWTH-HORMONE IN UNANESTHETIZED RATS [J].