A STUDY ON THE EFFECT OF HYDROXYETHYLRUTOSIDE ON TRANSCUTANEOUS OXYGEN-TENSION MEASUREMENTS IN PATIENTS WITH SEVERE VENOUS INSUFFICIENCY

被引：7

作者：

QUIGLEY, FG

FARIS, IB

机构：

[1] Vascular Surgery, University of Adelaide, Royal Adelaide Hospital, Adelaide

[2] Surgery, University of Adelaide, Royal Adelaide Hospital, Adelaide

来源：

VASCULAR SURGERY | 1991年 / 25卷 / 01期

关键词：

D O I：

10.1177/153857449102500107

中图分类号：

R61 [外科手术学];

学科分类号：

摘要：

Chronic venous insufficiency is thought to cause tissue hypoxia and ulceration through pericapillary deposition of fibrin. Transcutaneous tissue oxygen tension measurements (TCpO2) were made on 17 patients with severe venous insufficiency and repeated after three and six months of treatment with O-(B-hydroxyethyl)-rutosides, a drug recommended for treatment of venous insufficiency that is thought to enhance tissue fibrinolysis. After six month's treatment, TCpO2 measurements were significantly better than initial values (0.01 < p < 0.05). This improvement in TCpO2 measurements is consistent with the hypothesis that O-(B-hydroxyethyl)-rutosides act by enhancing tissue fibrinolysis and might reduce the pericapillary fibrin that is thought to be a major factor in the pathogenesis of venous ulceration.

引用

页码：42 / 47

页数：6

共 9 条

[1]

Browse N.L., Burnand K.G., The cause of venous ulceration, The Lancet, pp. 243-245, (1982)

[2]

Clyne C., Et al., Oxygen tension on the skin of the gaiter area of limbs with venous disease, BrJ Surg, 72, pp. 644-647, (1985)

[3]

Moosa H.H., Et al., Oxygen diffusion in chronic venous ulceration, J Cardiovasc Surg, 28, pp. 464-467, (1987)

[4]

Quigley F.G., Faris I.B., Transcutaneous oxygen potentials in venous disease, Aust NZJ Surg, 59, pp. 165-168, (1989)

[5]

Piller N.B., Casley-Smith J.R., The effect of coumarin on protein and PVP clearance from rat legs and various high protein oedemas, Br J Exp Path, 56, pp. 439-443, (1975)

[6]

Hoare M.D., Royle J.P., Doppler ultrasound detection of saphenofemoral and saphenopopliteal incompetence and operative venography to ensure precise saphenopopliteal ligation, Aust NZJ Surg, 54, pp. 49-52, (1984)

[7]

Hauser C.J., Schoemaker W.E., Use of a transcutaneous PO2 regional perfusion index to quantify tissue perfusion in peripheral vascular disease, Ann Sug, 197, pp. 337-343, (1983)

[8]

Browse N.L., Jarrett P., Marland M., Burnard K., Et al., Treatment of liposclerosis of the leg by fibrinolytic enhancement: A preliminary report, Br Med J, 2, pp. 434-435, (1977)

[9]

Casley-Smith J.R., Casley-Smith J.R., High protein oedemas and the benzo-pyrones Sydney, JB Lippincott Company, (1986)

← 1 →