HASHIMOTO, Y., SHIMA, T., MATSUKAWA, S. and IWATSUKI, K. Neuromuscular Blocking Property of Minocycline in the Rabbit. Tohoku J. exp. Med., 1979,129 (2), 203-204—The neuromuscular blocking property of minocycline hydrochloride (MNC) was studied in 12 rabbits. In 2 of 6 animais, MNC, 60-160 mg/kg, alone caused a decrease in twitch tension. During partial neuromuscular blockade produced by a continuous infusion of pancuronium, the intravenous administration of MNC, 20-60 mg/kg, resulted in a dose-dependent decrease in twitch tension in 6 animais. MNC-induced or combined MNC-pancuronium-induced neuromuscular blockade was antagonized by calcium or by neostigmine. —minocycline; neuromuscular transmission Prolonged neuromuscular blockade is a well-known adverse effect that follows administration of antibiotics. The tetracycline group of antibiotics producing neuromuscular blockade includes tetracycline, oxy-tetracycline, and roli-tetracycline (Pittinger et al. 1970). Minocycline hydrochloride (MNC) is structurally related to the tetracycline group of antibiotics. The effects of MNC on the neuromuscular transmission have not been reported. Therefore, this study was undertaken to examine the neuromuscular blocking properties of MNC in the rabbit. © 1979, Tohoku University Medical Press. All rights reserved.
