EFFECT OF INDOMETHACIN PLUS RANITIDINE IN ADVANCED MELANOMA PATIENTS ON HIGH-DOSE INTERLEUKIN-2

被引：24

作者：

MERTENS, WC

BRAMWELL, VHC

GWADRYSRIDHAR, F

ROMANO, W

BANERJEE, D

LALA, PK

机构：

[1] UNIV MICHIGAN,DEPT RADIOL,ANN ARBOR,MI 48109

[2] UNIV WESTERN ONTARIO,DEPT PATHOL,LONDON N6A 3K7,ONTARIO,CANADA

[3] UNIV WESTERN ONTARIO,DEPT ANAT,LONDON N6A 3K7,ONTARIO,CANADA

来源：

LANCET | 1992年 / 340卷 / 8816期

关键词：

D O I：

10.1016/0140-6736(92)91474-M

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Preclinical models of advanced melanoma have shown that chronic indomethacin therapy combined with interleukin 2 (IL-2) can eradicate experimental metastases. A phase II trial was done in patients with advanced melanoma. Indomethacin and ranitidine were begun at least one week before IL-2. Of the objective responses in 3 patients, 2 were achieved on ranitidine and indomethacin alone, before start of IL-2. Indomethacin and ranitidine may be responsible for some responses in melanoma patients previously attributed to IL-2.

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收藏

页码：397 / 398

页数：2

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