Statistical analysis of bioassays, based on hazard modelling

被引：73

作者：

Bedaux, J. J. M. ^{[1
]}

Kooijman, S. A. L. M. ^{[1
]}

机构：

[1] Vrije Univ Amsterdam, Dept Theoret Biol, NL-1081 HV Amsterdam, Netherlands

来源：

ENVIRONMENTAL AND ECOLOGICAL STATISTICS | 1994年 / 1卷 / 04期

关键词：

killing rate; LC50; maximum likelihood; no-effect level; one-compartment model; quantal assay data; time dependent toxicity;

D O I：

10.1007/BF00469427

中图分类号：

X [环境科学、安全科学];

学科分类号：

08 ; 0830 ;

摘要：

A stochastic model is proposed to describe time-dependent lethal effects of toxic compounds. It is based on simple mechanistic assumptions and provides a measure for the toxicity of a chemical compound, the so-called killing rate. The killing rate seems a promising alternative for the LC50. The model also provides the no-effect level and the LC50, both as a function of exposure time. The model is applied to real data and to simulated data.

引用

页码：303 / 314

页数：12

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