SEROTONERGIC TERMINALS EXPRESS A GROWTH-ASSOCIATED PROTEIN (GAP-43) IN THE ADULT-RAT SPINAL-CORD

被引：26

作者：

CHING, YP

AVERILL, S

WILKIN, GP

WOTHERSPOON, G

PRIESTLEY, JV

机构：

[1] UMDS, ST THOMAS HOSP, DIV PHYSIOL, LONDON, ENGLAND

[2] UMDS, ST THOMAS HOSP, DIV BIOCHEM, LONDON, ENGLAND

[3] UNIV LONDON IMPERIAL COLL SCI & TECHNOL, DEPT BIOCHEM, LONDON, ENGLAND

来源：

NEUROSCIENCE LETTERS | 1994年 / 167卷 / 1-2期

基金：

英国惠康基金;

关键词：

SEROTONIN; GAP-43; SPINAL CORD; IMMUNOFLUORESCENCE; COEXISTENCE; MOTONEURON; DOUBLE LABELING;

D O I：

10.1016/0304-3940(94)91029-4

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Dual colour immunofluorescence has been used to compare the distribution of serotonin (5-hydroxytryptamine, 5-HT) and GAP-43 in the adult rat. GAP-43 immunostaining was observed in all spinal cord regions containing 5-HT immunoreactivity. 5-HT and GAP-43 double labelled fibres and varicosities were present and were most evident around motoneurones, in lamina X, and in the intermediolateral cell column. Single labelled GAP-43 fibres and varicosities were also observed and were the dominant population in the dorsal horn and in certain fibre tracts. We conclude that the 5-HT system is one of a small number of spinal cord systems that express high levels of GAP-43 in the adult.

引用

页码：67 / 72

页数：6

共 37 条

[1] ON THE DISTRIBUTION OF GAP-43 AND ITS RELATION TO SEROTONIN IN ADULT MONKEY AND CAT SPINAL-CORD AND LOWER BRAIN-STEM [J].