THE GENES FOR HUMAN BRAIN FACTOR-1 AND FACTOR-2, MEMBERS OF THE FORK HEAD GENE FAMILY, ARE CLUSTERED ON CHROMOSOME-14Q

被引：28

作者：

WIESE, S ^{[1
]}

MURPHY, DB ^{[1
]}

SCHLUNG, A ^{[1
]}

BURFEIND, P ^{[1
]}

SCHMUNDT, D ^{[1
]}

SCHNULLE, V ^{[1
]}

MATTEI, MG ^{[1
]}

THIES, U ^{[1
]}

机构：

[1] HOP ENFANTS LA TIMONE,CTR GENET MED,F-13385 MARSEILLE 5,FRANCE

来源：

BIOCHIMICA ET BIOPHYSICA ACTA-GENE STRUCTURE AND EXPRESSION | 1995年 / 1262卷 / 2-3期

基金：

澳大利亚研究理事会;

关键词：

TRANSCRIPTION FACTOR; FORK HEAD; TELENCEPHALON; NEURON; CHROMOSOME; 14Q; BRAIN FACTOR; (HUMAN);

D O I：

10.1016/0167-4781(95)00059-P

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Brain factor-1 (BF-1) is a member of the fork head gene family which shows expression restricted to the neurons of the developing telencephalon in rodents and man. We have isolated a second human gene (HBF-2), which is also strongly expressed in embryonic brain and has very high homology to both the rat and human brain factor-1 genes and the retroviral oncogene gin. The HBF-2 cDNA was isolated from a human fetal brain expression library and contains a putative open reading frame of 479 amino acids. The HBF-2 gene is strongly expressed in fetal brain and also with lower levels of expression in several adult tissues. At the genomic level the gene for HBF-1 contains an 500 bp intron situated between the DNA binding domain II and the fork head domain while that of HBF-2 is intronless. The two genes are clustered on human chromosome 14q11-13.

引用

页码：105 / 112

页数：8

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