ACETYL COENZYME A CARBOXYLASE - FILAMENTOUS NATURE OF ANIMAL ENZYMES

被引：70

作者：

KLEINSCH.AK

MOSS, J

LANE, MD

机构：

[1] Department of Biochemistry, New York University School of Medicine, New York

来源：

SCIENCE | 1969年 / 166卷 / 3910期

关键词：

D O I：

10.1126/science.166.3910.1276

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Acetyl coenzyme A carboxylases purified from several animal tissues exist as enzymatically active polymeric filaments of high molecular weight and have similar electron microscopic, hydrodynamic, and catalytic properties. These filaments reversibly dissociate into inactive protomers of uniform size. Their reassembly into catalytically active filaments is promoted by the presence of an allosteric activator.

引用

收藏

页码：1276 / &

相关论文

共 22 条

[1] ACETYL COA CARBOXYLASE .I. REQUIREMENT FOR 2 PROTEIN FRACTIONS [J].

ALBERTS, AW ;

VAGELOS, PR .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1968, 59 (02) :561-&

[2]

BLOOM W, 1968, TEXTBOOK HISTOLOGY, P169

[3] LIVER ACETYL COA CARBOXYLASE AND FATTY ACID SYNTHETASE - RELATIVE ACTIVITIES IN NORMAL STATE AND IN HEREDITARY OBESITY [J].

CHANG, HC ;

SEIDMAN, I ;

TEEBOR, G ;

LANE, MD .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1967, 28 (05) :682-&

[4] STUDIES ON THE MECHANISM OF FATTY ACID SYNTHESIS .7. BIOSYNTHESIS OF FATTY ACIDS FROM MALONYL COA [J].

GANGULY, J .

BIOCHIMICA ET BIOPHYSICA ACTA, 1960, 40 (01) :110-118

[5] HIGH CONTRAST STAINING OF INDIVIDUAL NUCLEIC ACID MOLECULES [J].

GORDON, CN ;

KLEINSCHMIDT, AK .

BIOCHIMICA ET BIOPHYSICA ACTA, 1968, 155 (01) :305-+

[6]

GREGOLIN C, 1968, J BIOL CHEM, V243, P4227

[7] MOLECULAR CHARACTERISTICS OF LIVER ACETYL COA CARBOXYLASE [J].

GREGOLIN, C ;

RYDER, E ;

KLEINSCHMIDT, AK ;

WARNER, RC ;

LANE, MD .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1966, 56 (01) :148-+

[8]

GREGOLIN C, 1968, J BIOL CHEM, V243, P4236

[9] LIVER ACETYL COA CARBOXYLASE - DISSOCIATION-REASSOCIATION PROCESS AND ITS RELATION TO CATALYTIC ACTIVITY [J].

GREGOLIN, C ;

RYDER, E ;

WARNER, RC ;

KLEINSCHMIDT, AK ;

LANE, MD .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1966, 56 (06) :1751-+

[10] A COMPARISON BETWEEN THE DIMENSIONS OF SOME MACROMOLECULES DETERMINED BY ELECTRON MICROSCOPY AND BY PHYSICAL CHEMICAL METHODS [J].

HALL, CE ;

DOTY, P .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1958, 80 (06) :1269-1274