CLINICAL APPLICABILITY OF CURRENT PHARMACOKINETIC MODELS - SPLANCHNIC ELIMINATION OF 5-FLUOROURACIL IN CANCER-PATIENTS

被引：15

作者：

ROBINSON, PJ

BASS, L

POND, SM

ROBERTS, MS

WAGNER, JG

机构：

[1] UNIV QUEENSLAND,DEPT MATH,ST LUCIA,QLD 4067,AUSTRALIA

[2] UNIV QUEENSLAND,DEPT MATH,BRISBANE,QLD 4000,AUSTRALIA

[3] UNIV QUEENSLAND,DEPT MED,BRISBANE,QLD 4000,AUSTRALIA

[4] UNIV OTAGO,SCH PHARM,DUNEDIN,NEW ZEALAND

[5] UNIV MICHIGAN,SCH PHARM,DEPT PHARMACOL,ANN ARBOR,MI 48109

[6] UNIV MICHIGAN,UPJOHN CTR CLIN PHARMACOL,ANN ARBOR,MI 48109

来源：

JOURNAL OF PHARMACOKINETICS AND BIOPHARMACEUTICS | 1988年 / 16卷 / 03期

关键词：

D O I：

10.1007/BF01062135

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

引用

页码：229 / 249

页数：21

共 25 条

[1] SATURATION KINETICS IN HEPATIC DRUG REMOVAL - A STATISTICAL APPROACH TO FUNCTIONAL-HETEROGENEITY [J].

BASS, L .

AMERICAN JOURNAL OF PHYSIOLOGY, 1983, 244 (06) :G583-G589

[2] EFFECTS OF CAPILLARY HETEROGENEITY ON RATES OF STEADY UPTAKE OF SUBSTANCES BY THE INTACT LIVER [J].

BASS, L ;

ROBINSON, PJ .

MICROVASCULAR RESEARCH, 1981, 22 (01) :43-57

[3] ON THE RELATION BETWEEN EXTENDED FORMS OF THE SINUSOIDAL PERFUSION AND OF THE CONVECTION DISPERSION MODELS OF HEPATIC ELIMINATION [J].

BASS, L ;

ROBERTS, MS ;

ROBINSON, PJ .

JOURNAL OF THEORETICAL BIOLOGY, 1987, 126 (04) :457-482

[4] FLOW DEPENDENCE OF 1ST-ORDER UPTAKE OF SUBSTANCES BY HETEROGENEOUS PERFUSED ORGANS [J].

BASS, L .

JOURNAL OF THEORETICAL BIOLOGY, 1980, 86 (02) :365-376

[5] HEPATIC ELIMINATION OF FLOWING SUBSTRATES - DISTRIBUTED MODEL [J].

BASS, L ;

ROBINSON, P ;

BRACKEN, AJ .

JOURNAL OF THEORETICAL BIOLOGY, 1978, 72 (01) :161-184

[6]

BASS L, 1976, Journal of Theoretical Biology, V61, P393, DOI 10.1016/0022-5193(76)90026-6

[7] HOW SMALL IS THE FUNCTIONAL VARIABILITY OF LIVER SINUSOIDS [J].

BASS, L ;

ROBINSON, P .

JOURNAL OF THEORETICAL BIOLOGY, 1979, 81 (04) :761-769

[8]

BRANCH RA, 1973, DRUG METAB DISPOS, V1, P687

[9] CIRCULATORY PATHWAYS IN THE RAT LIVER AS REVEALED BY P-32 CHROMIC PHOSPHATE COLLOID UPTAKE IN THE ISOLATED PERFUSED LIVER PREPARATION [J].

BRAUER, RW ;

LEONG, GF ;

MCELROY, RF ;

HOLLOWAY, RJ .

AMERICAN JOURNAL OF PHYSIOLOGY, 1956, 184 (03) :593-598

[10]

CHADWICK M, 1972, CANCER RES, V32, P1045

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