OLIGOHYDRAMNIOS SEQUENCE AND RENAL TUBULAR MALFORMATION ASSOCIATED WITH MATERNAL ENALAPRIL USE

被引：60

作者：

CUNNIFF, C

JONES, KL

PHILLIPSON, J

BENIRSCHKE, K

SHORT, S

WUJEK, J

机构：

[1] UNIV CALIF SAN DIEGO,DEPT PEDIAT,DIV DYSMORPHOL,LA JOLLA,CA 92093

[2] UNIV CALIF SAN DIEGO,DEPT PEDIAT,DIV NEONATOL,LA JOLLA,CA 92093

[3] UNIV CALIF SAN DIEGO,DEPT PATHOL,LA JOLLA,CA 92093

[4] UNIV CALIF SAN DIEGO,DEPT REPROD MED,LA JOLLA,CA 92093

来源：

AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY | 1990年 / 162卷 / 01期

关键词：

angiotensin converting enzyme inhibitors; captopril; Enalapril; renal dysgenesis;

D O I：

10.1016/0002-9378(90)90846-Y

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

We present the case of a child who died of pulmonary hypoplasia as a result of the oligohydramnios sequence. The mother was taking enalapril, as well as propranolol and hydrochlorothiazide, for treatment of hypertension associated with systemic lupus erythematosus. Autopsy examination revealed severe renal tubular malformation. Correlation of animal data with previous case reports of neonatal anuria in association with maternal angiotensin converting enzyme inhibitors suggests that these agents may have a deleterious effect on fetal renal development and general well-being. © 1990.

引用

页码：187 / 189

页数：3

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