PARTIAL TRISOMY 1Q IN IDIOPATHIC MYELOFIBROSIS

被引：16

作者：

DONTI, E ^{[1
]}

TABILIO, A ^{[1
]}

BOCCHINI, F ^{[1
]}

FALZETTI, F ^{[1
]}

MARTELLI, MF ^{[1
]}

GRIGNANI, F ^{[1
]}

DONTI, GV ^{[1
]}

机构：

[1] UNIV PERUGIA,MONTELUCE POLICLIN,IST CLIN MED 1,CATTEDRA GENET UMANA,I-06100 PERUGIA,ITALY

来源：

LEUKEMIA RESEARCH | 1990年 / 14卷 / 11-12期

关键词：

IDIOPATHIC MYELOFIBROSIS; MYELOID DISORDERS; CYTOGENETICS; TRISOMY; 1Q;

D O I：

10.1016/0145-2126(90)90117-R

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Three cases of idiopathic myelofibrosis with partial trisomy of the long arm of chromosome 1 are described. Partial trisomy 1q was the only karyotypic change detectable in unstimulated peripheral blood cell cultures of one and bone-marrow cultures of two patients at diagnosis. The extra segment from chromosome 1 was located on different karyotype sites, i.e. 1qter, 1p34 and 6p22-23; 1q21-32 was the shortest overlapping region and the only trisomic segment in one of the three patients. These findings suggest that partial trisomy 1q is a primary chromosome aberration in myelofibrosis relevant in the pathogenesis of this hematologic disorder.

引用

页码：1035 / &

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