FUSIDIC ACID IS HIGHLY-ACTIVE AGAINST EXTRACELLULAR AND INTRACELLULAR MYCOBACTERIUM-LEPRAE

被引：16

作者：

FRANZBLAU, SG

BISWAS, AN

HARRIS, EB

机构：

[1] Laboratory Research Branch, G. W. Long Hansen's Dis. Ctr., Carville

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 1992年 / 36卷 / 01期

关键词：

D O I：

10.1128/AAC.36.1.92

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The activity of fusidic acid against Mycobacterium leprae was studied in axenic medium and in bacilli residing within mouse peritoneal macrophages. Activity was assessed by subsequent quantitation of bacillary radiorespirometric activity. Significant inhibition in both systems was observed at 0.156-mu-g/ml, and an approximately 50% reduction in activity occurred after exposure to 1.25 to 2.5-mu-g/ml. The excellent human pharmacokinetics and in vitro activity of fusidic acid against the leprosy bacillus warrant a clinical trial of this drug for leprosy.

引用

页码：92 / 94

页数：3

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