ANTIVIRAL ACTIVITY OF THE PHOTOACTIVE PLANT PIGMENT HYPERICIN

被引：108

作者：

LOPEZBAZZOCCHI, I

HUDSON, JB

TOWERS, GHN

机构：

[1] UNIV BRITISH COLUMBIA,DIV MED MICROBIOL,VANCOUVER V5Z 1M9,BC,CANADA

[2] UNIV BRITISH COLUMBIA,DEPT BOT,VANCOUVER V5Z 1M9,BC,CANADA

来源：

PHOTOCHEMISTRY AND PHOTOBIOLOGY | 1991年 / 54卷 / 01期

关键词：

D O I：

10.1111/j.1751-1097.1991.tb01990.x

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The polycyclic compound hypericin, a known photodynamic agent, was investigated for antiviral activity in the presence and absence of light. The three viruses tested: murine cytomegalovirus; Sindbis virus; and human immunodeficiency virus type 1, were all susceptible to hypericin; but these antiviral activities were considerably enhanced, in a dose-dependent manner, by exposure to light.

引用

收藏

页码：95 / 98

页数：4

相关论文

共 15 条

[1] TOTALSYNTHESE DES HYPERICINS [J].

BROCKMANN, H ;

KLUGE, F ;

MUXFELDT, H .

CHEMISCHE BERICHTE-RECUEIL, 1957, 90 (10) :2302-2318

[2] HYPERICIN AND ITS PHOTODYNAMIC-ACTION [J].

DURAN, N ;

SONG, PS .

PHOTOCHEMISTRY AND PHOTOBIOLOGY, 1986, 43 (06) :677-680

[3] HUMAN IMMUNODEFICIENCY VIRUS INDUCES PHOSPHORYLATION OF ITS CELL-SURFACE RECEPTOR [J].

FIELDS, AP ;

BEDNARIK, DP ;

HESS, A ;

MAY, WS .

NATURE, 1988, 333 (6170) :278-280

[4]

Giese A.C., 1980, PHOTOCHEMICAL AND PHOTOBIOLOGICAL REVIEWS, V5, P229

[5] ANTIVIRAL PROPERTIES OF PHOTOSENSITIZERS [J].

HUDSON, JB ;

TOWERS, GHN .

PHOTOCHEMISTRY AND PHOTOBIOLOGY, 1988, 48 (03) :289-296

[6] NATURE OF THE INTERACTION BETWEEN THE PHOTOACTIVE COMPOUND PHENYLHEPTATRIYNE AND ANIMAL VIRUSES [J].

HUDSON, JB ;

GRAHAM, EA ;

TOWERS, GHN .

PHOTOCHEMISTRY AND PHOTOBIOLOGY, 1982, 36 (02) :181-185

[7]

Hudson JB, 1989, ANTIVIRAL COMPOUNDS

[8] ISOLATION AND ACTIVITY OF THE PHOTODYNAMIC PIGMENT HYPERICIN [J].

KNOX, JP ;

DODGE, AD .

PLANT CELL AND ENVIRONMENT, 1985, 8 (01) :19-25

[9] STUDIES OF THE MECHANISMS OF ACTION OF THE ANTIRETROVIRAL AGENTS HYPERICIN AND PSEUDOHYPERICIN [J].

LAVIE, G ;

VALENTINE, F ;

LEVIN, B ;

MAZUR, Y ;

GALLO, G ;

LAVIE, D ;

WEINER, D ;

MERUELO, D .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1989, 86 (15) :5963-5967

[10] THERAPEUTIC AGENTS WITH DRAMATIC ANTIRETROVIRAL ACTIVITY AND LITTLE TOXICITY AT EFFECTIVE DOSES - AROMATIC POLYCYCLIC DIONES HYPERICIN AND PSEUDOHYPERICIN [J].

MERUELO, D ;

LAVIE, G ;

LAVIE, D .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1988, 85 (14) :5230-5234