REGULATION OF SEROTONIN-INDUCED CALCIUM-UPTAKE IN SPISULA OOCYTES BY TRICYCLIC ANTIDEPRESSANTS

被引：8

作者：

JUNEJA, R

UENO, H

SEGAL, SJ

KOIDE, SS

机构：

[1] POPULAT COUNCIL,CTR BIOMED RES,1230 YORK AVE,NEW YORK,NY 10021

[2] MARINE BIOL LAB,WOODS HOLE,MA 02543

[3] OSAKA MED COLL,DEPT BIOCHEM,TAKATSUKI,OSAKA 569,JAPAN

来源：

NEUROSCIENCE LETTERS | 1993年 / 151卷 / 01期

关键词：

TRICYCLIC ANTIDEPRESSANTS; 5-HYDROXYTRYPTAMINE (SEROTONIN); CA-2(+) UPTAKE; SPISULA OOCYTE; OOCYTE MATURATION; GERMINAL VESICLE BREAKDOWN;

D O I：

10.1016/0304-3940(93)90056-Q

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The effect of tricyclic antidepressants on 5-hydroxytryptamine (serotonin or 5-HT)-induced maturation and Ca2+ uptake in Spisula oocytes was determined. The drugs at a concentration of 20 muM completely blocked germinal vesicle breakdown and Ca-45(2+) uptake by Spisula oocytes. The order of effectiveness of the antidepressants were imipramine > desipramine > clomipramine. The present findings suggest that the action of tricyclic antidepressants is to regulate Ca2+ uptake into 5-HT-responsive cells.

引用

页码：101 / 103

页数：3

共 13 条

[1]

AKAH PA, 1986, ARCH INT PHARMACOD T, V284, P231

[2] TRICYCLIC ANTIDEPRESSANT INHIBITION OF DEPOLARIZATION-INDUCED UPTAKE OF CALCIUM BY SYNAPTOSOMES FROM RAT-BRAIN [J].