GLUCOCORTICOID-INDUCED CHANGES IN LIVER - EFFECT OF DEXAMETHASONE ADMINISTRATION ON DNA TOPOISOMERASE-I AND TOPOISOMERASE-II ACTIVITIES AND DISTRIBUTION OF HISTONE-H1 SUBTYPES

被引：6

作者：

GOODLAD, GAJ

CLARK, CM

机构：

[1] Division of Cellular and Molecular Biology, School of Biological and Medical Sciences, University of St. Andrews, Fife, KY16 9AL, Irvine Building, St. Andrews

来源：

CELL BIOCHEMISTRY AND FUNCTION | 1994年 / 12卷 / 04期

关键词：

RAT LIVER; DEXAMETHASONE; DNA TOPOISOMERASE I AND II; H1; HISTONES;

D O I：

10.1002/cbf.290120404

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The activities of DNA topoisomerase I and II and the relative proportions of the histone H1 subtypes were investigated in rat liver which was undergoing hypertrophy and exhibiting increased transcriptional activity following the administration of dexamethasone. There was a rise in the level of activity of DNA topoisomerase I and a slight fall in that of DNA topoisomerase II. The relative proportions of the H1 subtypes were altered due to a preferential increase in H1.1. The results are discussed in relation to the effect of glucocorticoids on the transcription and replication of hepatic DNA.

引用

页码：247 / 253

页数：7

共 37 条

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