A SEVERE LOSS OF CHOLINE-ACETYLTRANSFERASE IN THE FRONTAL-CORTEX OF ALZHEIMER PATIENTS CARRYING APOLIPOPROTEIN EPSILON-4 ALLELE

被引：146

作者：

SOININEN, H

KOSUNEN, O

HELISALMI, S

MANNERMAA, A

PALJARVI, L

TALASNIEMI, S

RYYNANEN, M

RIEKKINEN, P

机构：

[1] UNIV KUOPIO,DEPT PATHOL,SF-70211 KUOPIO,FINLAND

[2] KUOPIO UNIV HOSP,DEPT GYNECOL & OBSTET,CLIN GENET UNIT,SF-70211 KUOPIO,FINLAND

[3] HARJULA HOSP,SF-70211 KUOPIO,FINLAND

[4] UNIV KUOPIO,AI VIRTANEN INST,SF-70211 KUOPIO,FINLAND

来源：

NEUROSCIENCE LETTERS | 1995年 / 187卷 / 02期

关键词：

ALZHEIMERS DISEASE; APOLIPOPROTEIN E; CHOLINE ACETYLTRANSFERASE; FRONTAL CORTEX;

D O I：

10.1016/0304-3940(95)11343-6

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

We measured the activities of choline acetyltransferase (ChAT) in the post mortem frontal cortex in 32 Alzheimer's disease (AD) patients with different apolipoprotein E (apoE) genotypes. The ChAT values were significantly lower for the AD patients with 2 epsilon 4 alleles than for those with 0 epsilon 4 (ANOVA, P < 0.05). The ChAT activities of AD patients carrying 2 or 1 epsilon 4 alleles and those without the epsilon 4 allele also differed significantly: 16.3 +/- 15.2 versus 30.5 +/- 20.6 pmol/mg protein per min, ANOVA, P < 0.05. However, the AD patients carrying the epsilon 4 allele were significantly younger than those with 0 epsilon 4 allele. The study indicates that AD patients carrying the epsilon 4 allele have a more severe cholinergic deficit than the AD patients without the epsilon 4 allele.

引用

页码：79 / 82

页数：4

共 23 条

[1] ALZHEIMERS-DISEASE - CHOLINE-ACETYLTRANSFERASE ACTIVITY IN BRAIN-TISSUE FROM CLINICAL AND PATHOLOGICAL SUBGROUPS [J].