ELEVATED PLASMA INTERLEUKIN-6 LEVELS IN PATIENTS WITH ACUTE MYOCARDIAL-INFARCTION

被引：168

作者：

MIYAO, Y ^{[1
]}

YASUE, H ^{[1
]}

OGAWA, H ^{[1
]}

MISUMI, I ^{[1
]}

MASUDA, T ^{[1
]}

SAKAMOTO, T ^{[1
]}

MORITA, E ^{[1
]}

机构：

[1] KUMAMOTO UNIV,SCH MED,DIV CARDIOL,1-1-1 HONJO,KUMAMOTO 860,JAPAN

来源：

AMERICAN HEART JOURNAL | 1993年 / 126卷 / 06期

关键词：

D O I：

10.1016/0002-8703(93)90526-F

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Interleukin-6 (IL-6) plays a key role in the synthesis of human acute-phase protein and several acute-phase responses occur in patients with acute myocardial infarction (AMI). We examined the plasma levels of IL-6 in 23 consecutive patients with AMI over the course of 4 weeks and in 30 control subjects. In patients with AMI, the plasma IL-6 levels (in picograms per milliliter) were increased at all sampling points from admission to discharge (ranging from 28.5 +/- 6.6 to 46.5 +/- 7.8) compared with levels in control subjects (11.4 +/- 2.9; p < 0.01). Cardiac catheterization did not influence plasma IL-6 levels. The plasma IL-6 level reached its peak approximately 3 days (46.5 +/- 7.8) and approximately 1 week after admission in patients with AMI. There was a significant positive linear correlation between the peak level of plasma IL-6 minus the level on admission and the peak level of plasma C-reactive protein in patients with AMI. The peak IL-6 level did not correlate with the peak levels of creatine kinase, pulmonary capillary wedge pressure, or left ventricular ejection fraction at 4 weeks. We conclude that the plasma IL-6 level is increased over a time course of 4 weeks in patients with AMI.

引用

页码：1299 / 1304

页数：6

共 30 条

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