ANEMIA DUE TO REDUCED SERUM ERYTHROPOIETIN CONCENTRATION IN NON-UREMIC DIABETIC-PATIENTS

被引：35

作者：

KOJIMA, K

TOTSUKA, Y

机构：

[1] Department of Endocrinology and Metabolism, Diabetes Center, Konto Teishin Hospital, Shinagawa, Tokyo

来源：

DIABETES RESEARCH AND CLINICAL PRACTICE | 1995年 / 27卷 / 03期

关键词：

ERYTHROPOIETIN; ANEMIA; AUTONOMIC NEUROPATHY; DIABETES MELLITUS;

D O I：

10.1016/0168-8227(95)01042-C

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

We encountered two patients with non-insulin-dependent diabetes mellitus (DM) who developed normocytic normochromic anemia, Routine hematological examinations revealed no specific causes except for the reduced serum levels of erythropoietin. Since their renal functions were preserved, the anemias may not have been due to chronic renal failure. Treatment with human recombinant erythropoietin (rHuEPO) improved anemia, ascribing the cause of anemia to low levels of erythropoietin in these patients. Underlying common clinical features of the two patients were longstanding poorly controlled diabetes mellitus accompanied with advanced neuropathy. Since erythropoietin production is regulated in part by autonomic nervous system, the results suggest that erythropoietin production could be prematurely impaired in patients with severe diabetic autonomic neuropathy.

引用

页码：229 / 233

页数：5

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