1-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROPYRIDINE (MPTP) TREATMENT DECREASES DOPAMINE AND INCREASES LIPOFUSCIN IN MOUSE RETINA

被引:34
作者
MARIANI, AP [1 ]
NEFF, NH [1 ]
HADJICONSTANTINOU, M [1 ]
机构
[1] OHIO STATE UNIV,COLL MED,DEPT PHARMACOL,COLUMBUS,OH 43210
关键词
D O I
10.1016/0304-3940(86)90084-4
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
引用
收藏
页码:221 / 226
页数:6
相关论文
共 16 条
[1]   A PRIMATE MODEL OF PARKINSONISM - SELECTIVE DESTRUCTION OF DOPAMINERGIC-NEURONS IN THE PARS COMPACTA OF THE SUBSTANTIA NIGRA BY N-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROPYRIDINE [J].
BURNS, RS ;
CHIUEH, CC ;
MARKEY, SP ;
EBERT, MH ;
JACOBOWITZ, DM ;
KOPIN, IJ .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1983, 80 (14) :4546-4550
[2]  
FEENEY L, 1978, INVEST OPHTH VIS SCI, V17, P583
[3]  
FULLER RW, 1985, J PHARMACOL EXP THER, V232, P696
[4]   WATER-STABLE FLUOROPHORES, PRODUCED BY REACTION WITH ALDEHYDE SOLUTIONS, FOR HISTOCHEMICAL LOCALIZATION OF CATECHOLAMINES AND INDOLETHYLAMINES [J].
FURNESS, JB ;
COSTA, M ;
WILSON, AJ .
HISTOCHEMISTRY, 1977, 52 (02) :159-170
[5]   MPTP ALTERS CENTRAL CATECHOLAMINE NEURONS IN ADDITION TO THE NIGROSTRIATAL SYSTEM [J].
GUPTA, M ;
FELTEN, DL ;
GASH, DM .
BRAIN RESEARCH BULLETIN, 1984, 13 (06) :737-742
[6]   CATECHOLAMINE SYSTEMS OF RETINA - A MODEL FOR STUDYING SYNAPTIC MECHANISMS [J].
HADJICONSTANTINOU, M ;
NEFF, NH .
LIFE SCIENCES, 1984, 35 (11) :1135-1147
[7]   EPINEPHRINE - A POTENTIAL NEUROTRANSMITTER IN RETINA [J].
HADJICONSTANTINOU, M ;
COHEN, J ;
NEFF, NH .
JOURNAL OF NEUROCHEMISTRY, 1983, 41 (05) :1440-1444
[8]   DOPAMINERGIC NEUROTOXICITY OF 1-METHYL-4-PHENYL-1,2,5,6-TETRAHYDROPYRIDINE IN MICE [J].
HEIKKILA, RE ;
HESS, A ;
DUVOISIN, RC .
SCIENCE, 1984, 224 (4656) :1451-1453
[9]  
HEIKKILA RE, 1984, NATURE, V311, P467, DOI 10.1038/311467a0
[10]   PARKINSONISM-INDUCING NEUROTOXIN, N-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROPYRIDINE - UPTAKE OF THE METABOLITE N-METHYL-4-PHENYLPYRIDINE BY DOPAMINE NEURONS EXPLAINS SELECTIVE TOXICITY [J].
JAVITCH, JA ;
DAMATO, RJ ;
STRITTMATTER, SM ;
SNYDER, SH .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1985, 82 (07) :2173-2177