STUDY OF ENDOGENOUS FATTY ACIDS OF LYMPHATIC CHYLOMICRONS TRIGLYCERIDES IN RAT AFTER ADMINISTRATION OF VARIOUS MIXED LABELED TRIGLYCERIDES

Rats with cannulated thoracic ducts received one or several meals containing various quantities of mixed triglycerides with 2 or 4 different labeled fatty acids. The composition of endogenous and exogenous fatty acids of the lymphatic chylomicrons triglycerides was determined by gas-liquid chromatography and by radioactivity determinations. Whatever the nature and the amounts of the triglycerides fed, the quantities of endogenous fatty acids and the proportions of each of them vary little for lymph collection time of 14-16 h. These results offer an explanation for the variations, observed by different authors, in the extent of the dilution by endogenous acids in the lymph; their meaning as to the origin of these endogenous lipids was also discussed. © 1968.