INDIVIDUAL ADENOVIRUS E1B PROTEINS INDUCE TRANSFORMATION INDEPENDENTLY BUT BY ADDITIVE PATHWAYS

被引：44

作者：

MCLORIE, W

MCGLADE, CJ

TAKAYESU, D

BRANTON, PE

机构：

[1] MCMASTER UNIV, DEPT PATHOL, HAMILTON L8N 3Z5, ONTARIO, CANADA

[2] MCMASTER UNIV, DEPT BIOL, HAMILTON L8N 3Z5, ONTARIO, CANADA

[3] MCMASTER UNIV, MOLEC VIROL & IMMUNOL PROGRAMME, HAMILTON L8N 3Z5, ONTARIO, CANADA

来源：

JOURNAL OF GENERAL VIROLOGY | 1991年 / 72卷

关键词：

D O I：

10.1099/0022-1317-72-6-1467

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

The specific contributions of human adenovirus type 5 early region 1B (E1B) proteins were examined using mutants which synthesize these products individually. In cooperation with E1A, transformation of primary baby rat kidney cells was achieved with either the 176R protein or 496R protein alone, albeit at an efficiency considerably less than that observed when both were present. These results indicate that transformation mediated by either E1B product can proceed independently, but that the processes involved are additive.

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页码：1467 / 1471

页数：5

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