HYDROPHILIC AND HYDROPHOBIC POLYMERIC DERIVATIVES OF ANTIINFLAMMATORY AGENTS SUCH AS ALCLOFENAC, KETOPROFEN, AND IBUPROFEN

被引：50

作者：

GIAMMONA, G

CARLISI, B

PITARRESI, G

FONTANA, G

机构：

[1] Dipartimento di Chimica e Tecnologie Farmaceutiche Universita'di Palermo, Palermo

来源：

JOURNAL OF BIOACTIVE AND COMPATIBLE POLYMERS | 1991年 / 6卷 / 02期

关键词：

D O I：

10.1177/088391159100600202

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Macromolecular prodrugs of a hydrophilic polymer [alpha,beta-poly(N-hydroxyethyl)DL-aspartamide (PHEA)] was used as a drug carrier. Three poly-(HEA)-NSAID adducts were studied: poly(HEA)-Alclofenac, poly(HEA)-Keto-profen, and poly(HEA)-Ibuprofen. Prodrugs with different drug content were synthesized both as water-soluble and water-insoluble agents. Hydrolysis of water-soluble adducts in a simulated gastric juice was studied.

引用

页码：129 / 141

页数：13

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