BENZOPYRANYL-CYANOGUANIDINE POTASSIUM CHANNEL OPENERS

被引：18

作者：

ATWAL, KS

MORELAND, S

MCCULLOUGH, JR

AHMED, SZ

NORMANDIN, DE

机构：

[1] Bristol-Myers Squibb, Pharmaceutical Research Institute, N. J. 08543-4000, P.O. Box 4000, Princeton

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1992年 / 2卷 / 01期

关键词：

D O I：

10.1016/S0960-894X(00)80662-9

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

To further investigate whether potassium channel openers cromakalim (1) and pinacidil (2) share common pharmacophoric features, the cyanoguanidine analog 4a of cromakalim (1) was prepared and evaluated for biological activity. The potent vasorelaxing activity displayed by 4a and some of its analogs support the hypothesis that cromakalim (1) and pinacidil (2) share common pharmacophoric features.

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页码：87 / 90

页数：4

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