INVITRO ANTIVIRAL ACTIVITY OF POLYOXOMOLYBDATES - MECHANISM OF INHIBITORY EFFECT OF PM-104 (NH4)12H2(EU4(MOO4)(H2O)16(MO7O24)4) . 13H2O ON HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1

被引：63

作者：

INOUYE, Y

TOKUTAKE, Y

YOSHIDA, T

SETO, Y

HUJITA, H

DAN, K

YAMAMOTO, A

NISHIYA, S

YAMASE, T

NAKAMURA, S

机构：

[1] HIROSHIMA UNIV,SCH MED,DEPT MICROBIOL,HIROSHIMA 730,JAPAN

[2] KEIO UNIV,SCH MED,INST PHARMACEUT,TOKYO 108,JAPAN

[3] TOKYO INST TECHNOL,RESOURCES UTILIZAT RES LAB,YOKOHAMA,KANAGAWA 227,JAPAN

[4] TERUMO CO LTD,CTR RES & DEV,KANAGAWA,JAPAN

来源：

ANTIVIRAL RESEARCH | 1993年 / 20卷 / 04期

关键词：

D O I：

10.1016/0166-3542(93)90075-T

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

A screening for inhibitors of human immunodeficiency virus type 1 (HIV-1) among various types of isopolyoxomolybdates and heteropolyoxomolybdates was carried out by using an in vitro assay system measuring the cytopathogenicity of HIV-1 in CD4+ human MT-4 cells. A novel heteropolyoxomolybdate named PM-104 with the chemical formula (NH4)12H2(Eu4(MoO4)(H2O)16(Mo7O24)4) . 13H2O was found to be associated with potent anti-HIV-1 activity. PM-104 interferes with virus infection at a very early step such as adsorption and/or penetration into the cells. In addition to the cytopathic effect of HIV-1 on MT-4 cells, syncytium formation between mock-infected MOLT-4 cells and MOLT-4 cells chronically infected with either HIV-1 or HIV-2 is suppressed by PM-104. PM-104 also blocks the replication of herpes simplex virus type 1 (HSV-1) and type 2 (HSV-2). The antiviral properties of PM-104 could be attributed to the combined effect of europium atoms and its peculiar three-dimensional anion structure.

引用

页码：317 / 331

页数：15

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