NEW CONSTITUENTS FROM PYRACANTHA-COCCINEA LEAVES

From the leaves of Pyracantha coccinea (Rosaceae), we have isolated and identified four new compounds, 2'(3-methylbut-2-enyloxy)-6-methoxyangelicin (pyracanthin A) [1], 2'(3-methylbut-2-enyloxy)-6-hydroxyangelicin (pyracanthin B) (2), 5,7,3',4'-tetrahydroxy-7-0-[6"-O-(acetyl)-beta-D-glucopyranosyloxy)-flavanone (coccinoside A) [4], and 5,7,2',5'-tetrahydroxy-7-0-beta-D-glucopyranosyloxyflavanone (coccinoside B) [5), besides scopoletin, 5,7,2',5'-tetrahydroxyflavanone, borneolapiosylglucopyranoside, and beta-ionol glucopyranoside, never previously isolated from this genus. The new structures were established by detailed spectral studies including COSY, 2D H-1-C-13 direct chemical shift correlation (HETCOR), and 2D H-1-C-13 correlation via long range coupling (COLOC) nmr techniques. The known compounds were identified by ir and nmr spectral analyses.