SYNTHESIS OF [1',3',4'-H-3(3)]4-(5',6',7',8',-TETRAHYDRO-5',5',8',8'-TETRAMETHYL-2'-ANTHRACENYL)BENZOIC ACID FOR BINDING-STUDIES OF RETINOIC ACID RECEPTORS

被引：4

作者：

DAWSON, MI ^{[1
]}

HOBBS, PD ^{[1
]}

RHEE, SW ^{[1
]}

MORIMOTO, H ^{[1
]}

WILLIAMS, PG ^{[1
]}

机构：

[1] LAWRENCE BERKELEY LAB,NATL TRITIUM LABELING FACIL,BERKELEY,CA 94720

来源：

JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS | 1993年 / 33卷 / 07期

关键词：

RAR; RETINOIC ACID RECEPTOR; RETINOID; 1'; 3'; 4'-H-3(3)]4-(5'; 6'; 7'; 8'-TETRAHYDRO-5'; 5'; 8'; 8'-TETRAMETHYL-2'-ANTHRACENYL)BENZOIC ACID; H-3(3)]TTAB;

D O I：

10.1002/jlcr.2580330710

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

[1',3',4'-H-3(3)]4- (5', 6', 7', 8'-Tetrahydro-5', 5', 8',8'-tetramethyl-2'-anthracenyl)benzoic acid (specific activity 64 Ci/mmole) was synthesized by bromination of ethyl 4-(5',6',7',8'-tetrahydro-5',5',8',8'-tetramethyl-2'-anthracenyl)benzoate, followed by reductive debromination by tritium gas in the presence of 10% palladium on carbon and hydrolysis. H-1 and H-3 NMR spectroscopy was used to establish tritium at 1',3',4'-tetrahydroanthracenyl ring positions.

引用

页码：633 / 637

页数：5

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